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NCGC00092410
CAS No. 442898-34-2
NCGC00092410( —— )
Catalog No. M35213 CAS No. 442898-34-2
NCGC00092410 (ML008) is a glucocerebrosidase (GC) inhibitor with IC50 value of 31 nM. It can be used for the study of Gaucher disease caused by mutation of glucocerebrase gene.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 61 | In Stock |
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| 5MG | 55 | In Stock |
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| 10MG | 92 | In Stock |
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| 25MG | 181 | In Stock |
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| 50MG | 273 | In Stock |
|
| 100MG | 405 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 848 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNCGC00092410
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NoteResearch use only, not for human use.
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Brief DescriptionNCGC00092410 (ML008) is a glucocerebrosidase (GC) inhibitor with IC50 value of 31 nM. It can be used for the study of Gaucher disease caused by mutation of glucocerebrase gene.
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DescriptionNCGC00092410 is a potent, selective, and nonsugar glucocerebrosidase (GC) inhibitor, with an IC50 of 31 nM. NCGC00092410 shows no activity against the related hydrolases at concentrations up to 77 μM. NCGC00092410, a GC chaperone, and increases the activity and lysosomal localization of glucocerebrosidase in mutant cell lines. NCGC00092410 can be used for the research of Gaucher disease.
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In VitroNCGC00092410 (7.3-130 nM; 25 min) inhibits the GC activity at various substrate concentrations (10-150 μM) in a dose-dependent manner.NCGC00092410 (55-40 μM; 2 d) increases the GC activity in the N370S mutant fibroblasts.NCGC00092410 (40 μM; 60-72 h) increases the lysosomal localization of GC in gaucher fibroblasts.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorGlucosidase
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Research Area——
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Indication——
Chemical Information
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CAS Number442898-34-2
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Formula Weight353.46
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Molecular FormulaC21H27N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 41.67 mg/mL (117.89 mM; Ultrasonic )
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SMILESCc1cc(nc2ccc(NC(=O)C3CCCCC3)cc12)N1CCOCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zheng W, et, al. Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13192-7.?
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