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CDK12-IN-5
CAS No. 2651200-35-8
CDK12-IN-5( —— )
Catalog No. M35197 CAS No. 2651200-35-8
CDK12-IN-5 is a potent CDK12 inhibitor with potential anticancer and antitumor activity, and can be used orally in the study of breast and ovarian cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 255 | Get Quote |
|
| 5MG | 398 | Get Quote |
|
| 10MG | 645 | Get Quote |
|
| 25MG | 1279 | Get Quote |
|
| 50MG | 2015 | Get Quote |
|
| 100MG | 2673 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameCDK12-IN-5
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NoteResearch use only, not for human use.
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Brief DescriptionCDK12-IN-5 is a potent CDK12 inhibitor with potential anticancer and antitumor activity, and can be used orally in the study of breast and ovarian cancer.
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DescriptionCDK12-IN-5, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 23.9 nM at high ATP (2 mM). CDK12-IN-5 has no effect on CDK2/Cyclin E (IC50=173 μM) and CDK9/Cyclin T1 (IC50=127 μM) at high ATP (2 mM) (WO2021116178A1).
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In VitroCDK12-IN-5 (Example 426) inhibits BRCA1 MRNA expression in MDA-MB-231 cells (IC50=3.23 nM) and has no effect on CAL-120 cells. CDK12-IN-5 has antproliferative activity in MDA-MB-231 cells (IC50=4.19 nM) and CAL-120 cells (IC50=3.57 nM). CDK12-IN-5 has a inhibition IC50 CDK12 high ATP to Degradation DC50 CDK12 ratio of 32.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number2651200-35-8
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Formula Weight454.36
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Molecular FormulaC18H15F5N8O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (275.11 mM; Ultrasonic )
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SMILESFC=1C=CC=2N=C(NC2C1F)CNC3=NC(=NC4=C(C=NN34)C(F)(F)F)N5CCOCC5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kai Thede, et al. Pyrazolotriazines. WO2021116178A1.
molnova catalog
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