ART812( —— )

Catalog No. M35191 CAS No. 2607138-82-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

ART812
Note

Research use only, not for human use.
Brief Description

ART812 is an orally active inhibitor of DNA polymerase Polθ, possessing an IC50 value of 7.6 nM. Additionally, ART812 exhibits a cell-based microhomology-mediated end joining (MMEJ) IC50 value of 240 nM.
Description

ART812 is an orally active DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM. ART812 has an IC50 value of 240 nM for cell based microhomology-mediated end joining (MMEJ).
In Vitro

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In Vivo

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Synonyms

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Pathway

Cell Cycle/DNA Damage
Target

DNA/RNA Synthesis
Recptor

DNA/RNA Synthesis
Research Area

——
Indication

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CAS Number

2607138-82-7
Formula Weight

461.79
Molecular Formula

C19H16ClF4N3O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (216.55 mM; Ultrasonic )
SMILES

CN(C(=O)[C@@H]1[C@H](O)[C@H](O)C(=O)N1c1cc(cc(C)n1)C(F)(F)F)c1ccc(F)c(Cl)c1
Chemical Name

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1. Zatreanu D, et al. Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance. Nat Commun. 2021 Jun 17;12(1):3636.?

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