(Iso)-MS4322( —— )

Catalog No. M35190 CAS No. 2601727-80-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

(Iso)-MS4322
Note

Research use only, not for human use.
Brief Description

(Iso)-MS4322 ((Iso)-YS43-22) is a selective and potent protein arginine methyltransferase 5 (PRMT5) degrader with potential anticancer activity that effectively reduces PRMT5 protein levels in MCF-7 cells and inhibits the growth of a wide range of cancer cells.
Description

MS4322 (YS43-22) isomer is an isomer of MS4322. MS4322 is a potent and selective PRMT5 (protein arginine methyltransferase 5) degrader, and inhibits growth of multiple cancer cell lines.
In Vitro

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In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

PROTACs | Histone Methyltransferase
Research Area

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Indication

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CAS Number

2601727-80-2
Formula Weight

1101.32
Molecular Formula

C55H76N10O12S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (45.40 mM; Ultrasonic )
SMILES

C[C@@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](NC(=O)COCCOCCOCCOCCOCC(=O)N1CC(C1)Nc1cc(ncn1)C(=O)NC[C@H](O)CN1CCc2ccccc2C1)C(C)(C)C)c1ccc(cc1)-c1scnc1C
Chemical Name

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1. Shen Y, et al. Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders. J Med Chem. 2020 Sep 10;63(17):9977-9989.?

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