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ARB-272572

CAS No. 2368182-63-0

ARB-272572( —— )

Catalog No. M35168 CAS No. 2368182-63-0

ARB-272572 is a potent inhibitor of programmed cell death ligand 1 (PD-L1) signaling that induces PD-L1 homodimer interactions and produces immunostimulatory activity in human primary cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 242 Get Quote
5MG 312 Get Quote
10MG 471 Get Quote
25MG 762 Get Quote
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Biological Information

  • Product Name
    ARB-272572
  • Note
    Research use only, not for human use.
  • Brief Description
    ARB-272572 is a potent inhibitor of programmed cell death ligand 1 (PD-L1) signaling that induces PD-L1 homodimer interactions and produces immunostimulatory activity in human primary cells.
  • Description
    ARB-272572 is a potent small-molecule PD-L1 inhibitor with an IC50 value of 400 pM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Immunology/Inflammation
  • Target
    PD-1/PD-L1
  • Recptor
    PD-1/PD-L1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2368182-63-0
  • Formula Weight
    568.67
  • Molecular Formula
    C32H36N6O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (219.81 mM; Ultrasonic )
  • SMILES
    O=C(NC1=CC=CC(C=2C=CC=C(NC(=O)C3=NC=C(C=C3)CNCCO)C2C)=C1C)C4=NC=C(C=C4)CNCCO
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Park JJ, et al. Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1. Nat Commun. 2021 Feb 22;12(1):1222. ?
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