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KSC-34
CAS No. 2226201-97-2
KSC-34( —— )
Catalog No. M35142 CAS No. 2226201-97-2
KSC-34 is a covalent modifier of protein disulfide isomerase A1 (PDIA1).KSC-34 is a selective inhibitor targeting the a-site of PDIA1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 226 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameKSC-34
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NoteResearch use only, not for human use.
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Brief DescriptionKSC-34 is a covalent modifier of protein disulfide isomerase A1 (PDIA1).KSC-34 is a selective inhibitor targeting the a-site of PDIA1.
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DescriptionKSC-34, a covalent modifier of protein disulfide isomerase A1 (PDIA1), is also a selective and potent a-site inhibitor of PDIA1 with an IC50 of 3.5 μM. KSC-34 displays a 30-fold selectivity for a domain over a′ domain and displays high selectivity for PDIA1 in complex proteomes with minimal engagement of other members of the PDI family. KSC-34 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number2226201-97-2
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Formula Weight429.95
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Molecular FormulaC21H28ClN7O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (232.59 mM; Ultrasonic )
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SMILESO=C(NCCNC1=NC(=NC(=N1)N(C)CCCCC=2C=CC=CC2)NCC#C)CCl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cole KS, et al. Characterization of an A-Site Selective Protein Disulfide Isomerase A1 Inhibitor. Biochemistry. 2018;57(13):2035-2043.?
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