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ZT-1a

CAS No. 212135-62-1

ZT-1a( —— )

Catalog No. M35128 CAS No. 212135-62-1

ZT-1a is a SPAK inhibitor.ZT-1a inhibits SPAK.ZT-1a can be used for the prevention and treatment of neurodegenerative and neurocognitive disorders.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	188	In Stock
5MG	170	In Stock
10MG	275	In Stock
25MG	377	In Stock
50MG	529	In Stock
100MG	Get Quote	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

ZT-1a
Note

Research use only, not for human use.
Brief Description

ZT-1a is a SPAK inhibitor.ZT-1a inhibits SPAK.ZT-1a can be used for the prevention and treatment of neurodegenerative and neurocognitive disorders.
Description

ZT-1a is a potent, non-ATP-competitive and selective SPAK inhibitor. ZT-1a inhibits SPAK activity with IC50s of 44.3, 35.0, 46.7 μM at ATP concentrations of 0.01, 0.1 and 1 mM, respectively.
In Vitro

——
In Vivo

Animal Model:Naive mice Dosage:10, 30, 50, and 100?mg/kg Administration:Intraperitoneal (i.p.) administration Result:Inhibited SPAK-dependent cation-Cl- cotransporters (CCC) phosphorylation in vivo.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

Chemical Information

CAS Number

212135-62-1
Formula Weight

445.73
Molecular Formula

C22H15Cl3N2O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (224.35 mM; Ultrasonic )
SMILES

Cc1cc(C(C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c1cc(Cl)ccc1O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Jinwei Zhang, et al. Modulation of Brain cation-Cl- Cotransport via the SPAK Kinase Inhibitor ZT-1a. Nat Commun. 2020 Jan 7;11(1):78.?

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