SQ609( —— )

Catalog No. M35027 CAS No. 627052-25-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SQ609
Note

Research use only, not for human use.
Brief Description

SQ609 is a potential anti-tuberculosis drug selected from a library of dipiperidine derivatives.
Description

SQ609 is a lead compound from a library of dipiperidines. SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells. SQ609 displays a potent antitubercular activity .
In Vitro

In Mtb-infected macrophages in vitro, SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells.
In Vivo

SQ609 (10 mg/kg; intravenous injection) completely prevents weight loss in the Mtb-infected animals and prolongs the therapeutic effect following drug withdrawal for another 10-15 days.Animal Model:TB susceptible mice (C3H/He)Dosage:10 mg/kg Administration:I.v.Result:Prevented weight loss in the Mtb-infected animals and prolonged the therapeutic effect following drug withdrawal for another 10-15 days.
Synonyms

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Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

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Indication

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1. Bogatcheva E, et al. Identification of SQ609 as a lead compound from a library of dipiperidines. Bioorg Med Chem Lett. 2011;21(18):5353-5357.?

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