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TH1217
CAS No. 1862212-48-3
TH1217( —— )
Catalog No. M35023 CAS No. 1862212-48-3
TH1217, a potent and selective inhibitor of dCTPase pyrophosphatase 1 (dCTPase), demonstrates an IC50 value of 47 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 94 | In Stock |
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| 2MG | 48 | In Stock |
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| 5MG | 77 | In Stock |
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| 10MG | 123 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTH1217
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NoteResearch use only, not for human use.
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Brief DescriptionTH1217, a potent and selective inhibitor of dCTPase pyrophosphatase 1 (dCTPase), demonstrates an IC50 value of 47 nM.
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DescriptionTH1217 (ZINC1775962367) is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19.
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In VitroTH1217 (compound 30) inhibits dCTPase and enhances aqueous solubility (>100 μM) and improves plasma stability in vitro(t4h=86%).TH1217 presents suitable mouse microsomal half-lives (109 minutes).TH1217 displays well cell permeability (8.66×10-6/1.30×10-3 cm/s) and CYP inhibition.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number1862212-48-3
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Formula Weight491.09
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Molecular FormulaC20H17BCl2N4O6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (254.54 mM; Ultrasonic )
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SMILESCc1nc2c(c(Cl)c(Cl)cc2n1Cc1ccc(cc1)[B-]12OC(=O)C[N+]1(C)CC(=O)O2)[N+]([O-])=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Llona-Minguez S, et, al. Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1. Med Chem. 2016 Feb 11; 59(3): 1140-1148.?
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