Thiodigalactoside

Research use only, not for human use.

Thiodigalactoside (TDG), a non-metabolizable disaccharide, serves as an orally active, potent galectin (GAL) inhibitor, exhibiting Kd values of 24 μM and 49 μM for GAL1 and GAL3, respectively.

Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with Kd values of 24 μM, 49 μM for GAL1 and GAL3, respectively. Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats.

Thiodigalactoside (TDG; 250 and 500?μM) exhibits dose-dependent reduction of fat accumulation based on triglyceride (TG) content and Oil Red O (ORO) staining.

Thiodigalactoside (TDG; 5?mg/kg; IP; once per week for 5 weeks) results in dramatic inhibition of HFD-induced body weight gain. Thiodigalactoside (5?mg/kg; oral; daily or weekly for 5 weeks) gave less reduction in body weight gain compare with i.p.. Animal Model:Five-week-old Sprague-Dawley (SD) male rats Dosage:5?mg/kg Administration:IP; once per week for 5 weeks Result:Resulted in dramatic inhibition of HFD-induced body weight gain by inhibiting adipogenesis and lipogensis as well as by increasing expression of the proteins associated with thermogenesis and energy expenditure.

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Cytoskeleton/Cell Adhesion Molecules

Galectin

Galectin

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51555-87-4

358.36

C12H22O10S

>98% (HPLC)

In Vitro:?H2O : 100 mg/mL (279.05 mM; Ultrasonic)

OC[C@H]1O[C@@H](S[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O

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(-20℃)

With Ice Pack

≥ 2 years