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3-Hydroxykynurenine
CAS No. 484-78-6
3-Hydroxykynurenine( —— )
Catalog No. M34973 CAS No. 484-78-6
3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) is an active metabolite of tryptophan and inhibits yeast and rat liver aldehyde dehydrogenase by 97 and 69%.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 29 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Name3-Hydroxykynurenine
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NoteResearch use only, not for human use.
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Brief Description3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) is an active metabolite of tryptophan and inhibits yeast and rat liver aldehyde dehydrogenase by 97 and 69%.
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Description3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis.
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In VitroCell Proliferation Assay Cell Line:CD3/CD28 bead-stimulated CD4+?T cells Concentration:0, 20, 40, 60, 80, and 100 μM Incubation Time:72 hours Result:Significantly inhibited CD4+?T-cell proliferation in a dose-dependent manner with an IC50?of approximately 70 μM.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number484-78-6
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Formula Weight224.21
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Molecular FormulaC10H12N2O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?1M HCl : 33.33 mg/mL (148.66 mM; Ultrasonic; (HCL ，pH≈1))
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SMILESNC(CC(=O)c1cccc(O)c1N)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. S Okuda,?et al. 3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity. J Neurochem.?1998 Jan;70(1):299-307.?
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