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Necrostatin-5
CAS No. 337349-54-9
Necrostatin-5( —— )
Catalog No. M34958 CAS No. 337349-54-9
Necrostatin-5 (Nec-5) is a selective RIP1 kinase inhibitor and cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with TNF-α, with an EC50 of 240 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 36 | In Stock |
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| 25MG | 84 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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Biological Information
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Product NameNecrostatin-5
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NoteResearch use only, not for human use.
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Brief DescriptionNecrostatin-5 (Nec-5) is a selective RIP1 kinase inhibitor and cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with TNF-α, with an EC50 of 240 nM.
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DescriptionNecrostatin-5 (Nec-5) is a potent necroptosis inhibitor with an EC50 value of 0.24 μM. Necrostatin-5 also is a RIP1 inhibitor. Necrostatin-5 shows cardioprotective effects.
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In Vitro——
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In VivoAnimal Model:200-300 g, male Wistar rats Dosage:2.46 mg/kg Administration:I.p.; 60 min before experiment Result:Reduced the infarction zone caused by 30-min global ischemia and 120-min reperfusion.
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Synonyms——
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PathwayApoptosis
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TargetRIP kinase
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RecptorRIP kinase | Necroptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number337349-54-9
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Formula Weight383.49
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Molecular FormulaC19H17N3O2S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 5 mg/mL (13.04 mM; Ultrasonic (<60°C)
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SMILESO=C1C=2C3=C(SC2N=C(SCC#N)N1C4=CC=C(OC)C=C4)CCCC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang K, et al. Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1455-65. ?
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