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PKUMDL-LC-101-D04

CAS No. 2143896-83-5

PKUMDL-LC-101-D04( —— )

Catalog No. M34896 CAS No. 2143896-83-5

PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of ferroptosis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 126 In Stock
5MG 154 In Stock
10MG 261 In Stock
25MG 377 In Stock
50MG 529 In Stock
100MG 731 In Stock
200MG 1014 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    PKUMDL-LC-101-D04
  • Note
    Research use only, not for human use.
  • Brief Description
    PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of ferroptosis.
  • Description
    PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a potent ferroptosis regulator glutathione peroxidase 4 (GPX4) allosteric activator (pEC50=4.7). PKUMDL-LC-101-D04 increases GPX4 activity to 150% at 20 μM in the cell-free assay and 61 μM in cell extracts.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    GPX
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2143896-83-5
  • Formula Weight
    378.94
  • Molecular Formula
    C14H23ClN4O2S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (659.74 mM; Ultrasonic )
  • SMILES
    Cl.NCCNS(=O)(=O)c1ccc(NC(=S)NC2CCCC2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Li C, et al. Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4. J Med Chem. 2019;62(1):266-275. ?
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