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PDE4B-IN-2
CAS No. 915082-52-9
PDE4B-IN-2( —— )
Catalog No. M34888 CAS No. 915082-52-9
PDE4B-IN-2 (A 33) is an orally active and selective PDE4B inhibitor with an IC50 of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC50=1.7 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 75 | In Stock |
|
| 5MG | 68 | In Stock |
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| 10MG | 107 | In Stock |
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| 25MG | 217 | In Stock |
|
| 50MG | 346 | In Stock |
|
| 100MG | 555 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1172 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePDE4B-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionPDE4B-IN-2 (A 33) is an orally active and selective PDE4B inhibitor with an IC50 of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC50=1.7 μM).
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DescriptionPDE4B-IN-2 is an orally active and selective PDE4B inhibitor with an IC50 of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC50=1.7 μM). PDE4B-IN-2 exhibits potent anti-inflammatory effects.
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In VitroPDE4B-IN-2 (compound 33) does not inhibit CYP1A2, CYP3A4, CYP2C9, and CYP2D (IC50>10 μM).PDE4B-IN-2 inhibits LPS-induced TNF-aproduction in vitro from mouseperipheral blood mononuclear cell (PBMC; IC50=0.5 M).
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In VivoPDE4B-IN-2 (compound 33; 2 mg/kg; po) has a Cmax of 8.7 μg/mL and an AUC of 52.3 μg?h/mL in mice.
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Synonyms——
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE
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Research Area——
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Indication——
Chemical Information
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CAS Number915082-52-9
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Formula Weight387.88
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Molecular FormulaC19H18ClN3O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (64.45 mM; Ultrasonic (<60°C)
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SMILESCCc1c(C)nc(nc1Nc1ccc(CC(O)=O)cc1)-c1ccc(Cl)s1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kenji Naganuma, et al. Discovery of selective PDE4B inhibitors. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3174-6.?
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