Cart
sales@molnova.com
PDE4B-IN-2
CAS No. 915082-52-9
PDE4B-IN-2( —— )
Catalog No. M34888 CAS No. 915082-52-9
PDE4B-IN-2 (A 33) is an orally active and selective PDE4B inhibitor with an IC50 of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC50=1.7 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 75 | In Stock |
|
| 5MG | 68 | In Stock |
|
| 10MG | 107 | In Stock |
|
| 25MG | 217 | In Stock |
|
| 50MG | 346 | In Stock |
|
| 100MG | 555 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1172 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePDE4B-IN-2
-
NoteResearch use only, not for human use.
-
Brief DescriptionPDE4B-IN-2 (A 33) is an orally active and selective PDE4B inhibitor with an IC50 of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC50=1.7 μM).
-
DescriptionPDE4B-IN-2 is an orally active and selective PDE4B inhibitor with an IC50 of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC50=1.7 μM). PDE4B-IN-2 exhibits potent anti-inflammatory effects.
-
In VitroPDE4B-IN-2 (compound 33) does not inhibit CYP1A2, CYP3A4, CYP2C9, and CYP2D (IC50>10 μM).PDE4B-IN-2 inhibits LPS-induced TNF-aproduction in vitro from mouseperipheral blood mononuclear cell (PBMC; IC50=0.5 M).
-
In VivoPDE4B-IN-2 (compound 33; 2 mg/kg; po) has a Cmax of 8.7 μg/mL and an AUC of 52.3 μg?h/mL in mice.
-
Synonyms——
-
PathwayAngiogenesis
-
TargetPDE
-
RecptorPDE
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number915082-52-9
-
Formula Weight387.88
-
Molecular FormulaC19H18ClN3O2S
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 25 mg/mL (64.45 mM; Ultrasonic (<60°C)
-
SMILESCCc1c(C)nc(nc1Nc1ccc(CC(O)=O)cc1)-c1ccc(Cl)s1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Kenji Naganuma, et al. Discovery of selective PDE4B inhibitors. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3174-6.?
molnova catalog
related products
-
Papaverine hydrochlo...
Papaverine hydrochloride is a selective phosphodiesterase inhibitor for the PDE10A subtype found mainly in the striatum of the brain.
-
BI 1015550
Nerandomilast (BI 1015550) is an orally active PDE4B inhibitor with IC50 of 7.2 nM. BI 1015550 has potential applications in inflammation, allergic diseases, pulmonary fibrosis and chronic obstructive pulmonary disease (COPD) with a good safety profile.
-
(R)-(-)-Rolipram
A more active enantiomer of the PDE4 inhibitor rolipram.
