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IL-4-inhibitor-1

CAS No. 1332184-63-0

IL-4-inhibitor-1( —— )

Catalog No. M34855 CAS No. 1332184-63-0

IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	132	In Stock
5MG	176	In Stock
10MG	330	In Stock
25MG	560	In Stock
50MG	783	In Stock
100MG	1079	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

IL-4-inhibitor-1
Note

Research use only, not for human use.
Brief Description

IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM).
Description

IL-4-inhibitor-1 (compound 52) is an IL-4 inhibitor, with an EC50 of 1.81 μM.
In Vitro

IL-4-inhibitor-1 (compound 52) displays low micromolar affinity and exhibits functional disruption of type II IL-4 binding in a cellular context.IL-4-inhibitor-1 (compound 52) exhibits dose-dependent reduction in pSTAT-6 levels with an EC50 value of 3.1 μM, but did not affect the levels of STAT-6.
In Vivo

——
Synonyms

——
Pathway

Apoptosis
Target

IL Receptor
Recptor

IL Receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

1332184-63-0
Formula Weight

321.31
Molecular Formula

C18H12FN3O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (311.23 mM; Ultrasonic )
SMILES

Nc1nc(cc(-c2ccc(O)c(O)c2)c1C#N)-c1ccc(F)cc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Sean P Quinnell, et al. A Small-Molecule Inhibitor to the Cytokine Interleukin-4. ACS Chem Biol. 2020 Oct 16;15(10):2649-2654.?

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