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IL-4-inhibitor-1
CAS No. 1332184-63-0
IL-4-inhibitor-1( —— )
Catalog No. M34855 CAS No. 1332184-63-0
IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 132 | In Stock |
|
| 5MG | 176 | In Stock |
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| 10MG | 330 | In Stock |
|
| 25MG | 560 | In Stock |
|
| 50MG | 783 | In Stock |
|
| 100MG | 1079 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIL-4-inhibitor-1
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NoteResearch use only, not for human use.
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Brief DescriptionIL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM).
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DescriptionIL-4-inhibitor-1 (compound 52) is an IL-4 inhibitor, with an EC50 of 1.81 μM.
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In VitroIL-4-inhibitor-1 (compound 52) displays low micromolar affinity and exhibits functional disruption of type II IL-4 binding in a cellular context.IL-4-inhibitor-1 (compound 52) exhibits dose-dependent reduction in pSTAT-6 levels with an EC50 value of 3.1 μM, but did not affect the levels of STAT-6.
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetIL Receptor
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RecptorIL Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1332184-63-0
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Formula Weight321.31
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Molecular FormulaC18H12FN3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (311.23 mM; Ultrasonic )
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SMILESNc1nc(cc(-c2ccc(O)c(O)c2)c1C#N)-c1ccc(F)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sean P Quinnell, et al. A Small-Molecule Inhibitor to the Cytokine Interleukin-4. ACS Chem Biol. 2020 Oct 16;15(10):2649-2654.?
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