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A2ti-2
CAS No. 482646-13-9
A2ti-2( —— )
Catalog No. M34841 CAS No. 482646-13-9
A2ti-2 is a low affinity and selective inhibitor of the membrane-bound protein A2/S100A10 heterotetramer (A2t) (IC50 : 230 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 255 | In Stock |
|
| 5MG | 231 | In Stock |
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| 10MG | 349 | In Stock |
|
| 25MG | 679 | In Stock |
|
| 50MG | 918 | In Stock |
|
| 100MG | 1265 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2539 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameA2ti-2
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NoteResearch use only, not for human use.
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Brief DescriptionA2ti-2 is a low affinity and selective inhibitor of the membrane-bound protein A2/S100A10 heterotetramer (A2t) (IC50 : 230 μM).
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DescriptionA2ti-2 is a selective and low-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 230 μM. A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2 prevents human papillomavirus type 16 (HPV16) infection.
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In VitroA2ti-2 (compound 7a) is an annexin A2-S100A10 protein-protein interaction blocker. A2ti-2 is less effective with <50% reduction in HPV16 PsV infection achieved at 100 μM. A2ti-1 decreases HPV16 entry with a 20% reduction at 100 μM.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorVirus Protease | Antiviral
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Research Area——
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Indication——
Chemical Information
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CAS Number482646-13-9
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Formula Weight354.43
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Molecular FormulaC18H18N4O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (705.36 mM; Ultrasonic )
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SMILESCc1ccccc1OCc1nnc(SCC(N)=O)n1-c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tummala R K Reddy, et al.Three-dimensional Pharmacophore Design and Biochemical Screening Identifies Substituted 1,2,4-triazoles as Inhibitors of the Annexin A2-S100A10 Protein Interaction. ChemMedChem. 2012 Aug;7(8):1435-46.?
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