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A2ti-2

CAS No. 482646-13-9

A2ti-2( —— )

Catalog No. M34841 CAS No. 482646-13-9

A2ti-2 is a low affinity and selective inhibitor of the membrane-bound protein A2/S100A10 heterotetramer (A2t) (IC50 : 230 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 255 In Stock
5MG 231 In Stock
10MG 349 In Stock
25MG 679 In Stock
50MG 918 In Stock
100MG 1265 In Stock
200MG Get Quote In Stock
500MG 2539 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    A2ti-2
  • Note
    Research use only, not for human use.
  • Brief Description
    A2ti-2 is a low affinity and selective inhibitor of the membrane-bound protein A2/S100A10 heterotetramer (A2t) (IC50 : 230 μM).
  • Description
    A2ti-2 is a selective and low-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 230 μM. A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2 prevents human papillomavirus type 16 (HPV16) infection.
  • In Vitro
    A2ti-2 (compound 7a) is an annexin A2-S100A10 protein-protein interaction blocker. A2ti-2 is less effective with <50% reduction in HPV16 PsV infection achieved at 100 μM. A2ti-1 decreases HPV16 entry with a 20% reduction at 100 μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Virus Protease | Antiviral
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    482646-13-9
  • Formula Weight
    354.43
  • Molecular Formula
    C18H18N4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (705.36 mM; Ultrasonic )
  • SMILES
    Cc1ccccc1OCc1nnc(SCC(N)=O)n1-c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tummala R K Reddy, et al.Three-dimensional Pharmacophore Design and Biochemical Screening Identifies Substituted 1,2,4-triazoles as Inhibitors of the Annexin A2-S100A10 Protein Interaction. ChemMedChem. 2012 Aug;7(8):1435-46.?
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