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AZD 3147
CAS No. 1101810-02-9
AZD 3147( —— )
Catalog No. M34825 CAS No. 1101810-02-9
AZD 3147 is an inhibitor of mTORC with IC50s of 40.7 and 5.75 nM for mTORC1 and mTORC2. AZD 3147 shows IC50s of 912, 5495, 9333, and 6310 nM for PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 149 | Get Quote |
|
| 5MG | 211 | Get Quote |
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| 10MG | 337 | Get Quote |
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| 25MG | 563 | Get Quote |
|
| 50MG | 753 | Get Quote |
|
| 100MG | 1017 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameAZD 3147
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NoteResearch use only, not for human use.
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Brief DescriptionAZD 3147 is an inhibitor of mTORC with IC50s of 40.7 and 5.75 nM for mTORC1 and mTORC2. AZD 3147 shows IC50s of 912, 5495, 9333, and 6310 nM for PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ, respectively.
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DescriptionAZD3147 is a potent, orally active, selective dual inhibitor of mTORC1 and mTORC2 with an IC50 value of 1.5 nM. AZD3147 also has a selective effect on PI3K.
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In VitroAZD3147 (0-50 nM, 1 h) can alleviate fibroblast growth factor (FGF)-mediated cilia extension at concentrations above 1.5 nM in NIH3T3 cells. AZD3147 inhibits cell viability of neuroblastoma cell lines Kelly and IMR-32 with the IC50 values of 0.88 nM and 662.4 nM, respectively.
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In VivoThe pharmacokinetic parameters of AZD3147.
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetmTOR
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RecptormTOR
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Research Area——
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Indication——
Chemical Information
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CAS Number1101810-02-9
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Formula Weight517.66
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Molecular FormulaC24H31N5O4S2
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Purity>98% (HPLC)
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Solubility——
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SMILESS(=O)(=O)(C1(CC1)C=2C=C(N=C(N2)C3=CC=C(NC(NCCO)=S)C=C3)N4[C@@H](C)COCC4)C5CC5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kurt G Pike, et al. Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2. J Med Chem. 2015 Mar 12;58(5):2326-49.
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