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4-hydroperoxy cyclophosphamide

CAS No. 39800-16-3

4-hydroperoxy cyclophosphamide( —— )

Catalog No. M34777 CAS No. 39800-16-3

4-hydroperoxy cyclophosphamide (4-OOH-CY) is an active metabolite of Cyclophosphamide that induces hepatotoxicity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    4-hydroperoxy cyclophosphamide
  • Note
    Research use only, not for human use.
  • Brief Description
    4-hydroperoxy cyclophosphamide (4-OOH-CY) is an active metabolite of Cyclophosphamide that induces hepatotoxicity.
  • Description
    4-Hydroperoxy cyclophosphamide is the active metabolite form of the precursor Cyclophosphamide. 4-Hydroperoxy cyclophosphamide cross-links DNA to induce T cell apoptosis independent of caspase receptor activation, and can activate the mitochondrial death pathway by producing reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide can be used in the study of rheumatoid arthritis and autoimmune diseases.
  • In Vitro
    Western Blot Analysis Cell Line:CTL Concentration:3 μg/mL Incubation Time:24, 48, 72 hResult:Increased the expression of p53 and Bax after 24 h.Apoptosis Analysis Cell Line:Jurkat, CTL Concentration:1 or 3 μg/mL Incubation Time:24 , 48 , 72h Result: Caspase-8 deficiency prevented CD95-mediated death induced by anti-CD95 monoclonal antibody (mAb) APO-1.Overexpression of Bcl-2 inhibited apoptosis. Induced cell death proceeded independently of caspase inhibition.
  • In Vivo
    Animal Model:BALB/c mice Dosage:200 mg/kg Administration:i.p.Result:Exhibited a marked depletion of immature double-positive CD4 t CD8 t thymocytes and mature single-positive CD4+ and CD8+ T cells.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Reactive Oxygen Species | DNA Alkylator/Crosslinker | Apoptosis | Drug Metabolite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    39800-16-3
  • Formula Weight
    293.09
  • Molecular Formula
    C7H15Cl2N2O4P
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (170.60 mM; Ultrasonic )
  • SMILES
    O=P1(OCCC(OO)N1)N(CCCl)CCCl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Strauss G, et al. 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. Cell Death Differ. 2008 Feb;15(2):332-43.?
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