Cart
sales@molnova.com
Mitoguazone
CAS No. 459-86-9
Mitoguazone( —— )
Catalog No. M34774 CAS No. 459-86-9
Mitoguazone (Methyl-GAG) is a selective S-adenosyl-methionine decarboxylase inhibitor that penetrates the blood-brain barrier and disrupts polyamine biosynthesis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 113 | In Stock |
|
| 10MG | 169 | In Stock |
|
| 25MG | 297 | In Stock |
|
| 50MG | 452 | In Stock |
|
| 100MG | 646 | In Stock |
|
| 500MG | 1323 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameMitoguazone
-
NoteResearch use only, not for human use.
-
Brief DescriptionMitoguazone (Methyl-GAG) is a selective S-adenosyl-methionine decarboxylase inhibitor that penetrates the blood-brain barrier and disrupts polyamine biosynthesis.
-
DescriptionMitoguazone (Methylglyoxal-bis(guanylhydrazone)) is a synthetic polycarbonyl derivative with potent antineoplastic activity. Mitoguazone is a brain-penetrant and competitive S-adenosyl-methionine decarboxylase (SAMDC) inhibitor that disrupts polyamine biosynthesis. Mitoguazone induces cell apoptosis. Mitoguazone inhibits HIV DNA integration into the cellular DNA in both monocytes and macrophages. Mitoguazone has the potential for acute leukemia, Hodgkin's and non-Hodgkin's lymphoma treatment.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayApoptosis
-
TargetApoptosis
-
RecptorApoptosis | HIV Protease
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number459-86-9
-
Formula Weight184.2
-
Molecular FormulaC5H12N8
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?H2O : 50 mg/mL (271.44 mM; ultrasonic and adjust pH to 9 with HCl)DMSO : 8.33 mg/mL (45.22 mM; Ultrasonic (<60°C)
-
SMILESC\C(\C=N\NC(N)=N)=N/NC(N)=N
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. J Rizzo, et al. Pharmacokinetic Profile of Mitoguazone (MGBG) in Patients With AIDS Related non-Hodgkin's Lymphoma. Invest New Drugs. 1996;14(2):227-34.?
molnova catalog
related products
-
Ceranib-2
Ceranib-2 is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells.
-
Myristoleic acid
Myristoleic acid is a cytotoxic component in the extract from Serenoa repens. Myristoleic acid induces apoptosis and necrosis in human prostatic LNCaP cells.
-
Bisindolylmaleimide ...
Bisindolylmaleimide VIII acetate is a potent and selective PKC inhibitor (IC50: 158 nM for rat brain PKC).
