Propanidid

Research use only, not for human use.

Propanidid (Sombrevin) is a gamma-aminobutyric acid type A receptor (GABAA) agonist and a fast-acting intravenous anesthetic that lowers arterial blood pressure.

Propanidid (Sombrevin; Fabantol) is a γ-aminobutyric acid type A (GABAA) receptor agonist and a short-acting non-barbiturate general anesthetic agent. Propanidid can decrease the arterial pressure.

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Propanidid (Sombrevin) (3-5 mg/kg; injected into the femoral vein; single dosage) changes the orientation tuning of 58 visual cortex neurons.Animal Model:Adult cats (immobilized by D-tubocurarine) Dosage:3-5 mg/kg Administration:Injected into the femoral vein; single dosage Result:A reliable change of the preferable orientation by 47.6 ± 5.6 degrees took place in 60% of 58 primary visual cortex neurons, while in the remaining cells it was stable in all stages of anaesthesia.The width of the orientation tuning changed reliably by 65.2 ± 6.7 degrees on the average in 55% of neurons, while in 31% of neurons the tuning acuteness was worse, but in 24% it was sharper.The preferable orientation, the width of the tuning and the frequency of the neuron discharge as a rule recovered in 30 min after the beginning of the anaesthesia.

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Others

Other Targets

GABA Receptor

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1421-14-3

337.41

C18H27NO5

>98% (HPLC)

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O=C(OCCC)CC1=CC=C(OCC(=O)N(CC)CC)C(OC)=C1

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(-20℃)

With Ice Pack

≥ 2 years