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Minalrestat

CAS No. 129688-50-2

Minalrestat( —— )

Catalog No. M34649 CAS No. 129688-50-2

Minalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Minalrestat
  • Note
    Research use only, not for human use.
  • Brief Description
    Minalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients.
  • Description
    Minalrestat (ARI-509) is a potent and orally active aldose reductase inhibitor. Minalrestat can be used in the research of diabetes.
  • In Vitro
    Western Blot Analysis Cell Line:Primary cultured rat mesangial cells Concentration:100 μM Incubation Time:48 h Result:Increased accumulation of PKC-α and -β2.
  • In Vivo
    Animal Model:Alloxan (40 mg/kg i.v.)-induced diabetic rats Dosage:10 mg/kg/day Administration:Oral gavage, for 30 days.Result:Restored the decreased microvascular reactivity.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    Reductase
  • Recptor
    Reductase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    129688-50-2
  • Formula Weight
    449.2
  • Molecular Formula
    C19H11BrF2N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1C2(C=3C(C(=O)N1CC4=C(F)C=C(Br)C=C4)=CC=C(F)C3)CC(=O)NC2=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Akamine EH, et al. Minalrestat, an aldose reductase inhibitor, corrects the impaired microvascular reactivity in diabetes. J Pharmacol Exp Ther. 2003 Mar;304(3):1236-42. ?
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