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Flovagatran

CAS No. 871576-03-3

Flovagatran( —— )

Catalog No. M34600 CAS No. 871576-03-3

Flovagatran (TGN 255) is an orally active, potent, and selective inhibitor of thrombin and parenteral direct factor II.Flovagatran is used to study venous thromboembolism.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Flovagatran
  • Note
    Research use only, not for human use.
  • Brief Description
    Flovagatran (TGN 255) is an orally active, potent, and selective inhibitor of thrombin and parenteral direct factor II.Flovagatran is used to study venous thromboembolism.
  • Description
    Flovagatran (TGN 255) is a potent and reversible thrombin inhibitor (Ki: 9 nM). Flovagatran can be used in the research of arterial and venous thrombosis.
  • In Vitro
    ——
  • In Vivo
    Flovagatran (2.5-mg/kg bolus plus 10 mg/kg/h for 90 minutes) produces anticoagulation effects in dogs.Animal Model:Chicks Dosage:1.0-mg/kg bolus and then 4 mg/kg/h for 90 minutes.2.5-mg/kg bolus and then 10 mg/kg/h for 90 minutes.5.0-mg/kg bolus and then 20 mg/kg/h for 90 minutes.Administration:Bolus plus infusion Result:Elevated PD markers, and produced minimal post-operative blood loss.
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    Thrombin
  • Recptor
    Thrombin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    871576-03-3
  • Formula Weight
    525.4
  • Molecular Formula
    C27H36BN3O7
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C([C@@H](CC1=CC=CC=C1)NC(OCC2=CC=CC=C2)=O)(=O)N3[C@H](C(N[C@@H](CCCOC)B(O)O)=O)CCC3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nelson DA, et al. Pharmacodynamic and efficacy profile of TGN 255, a novel direct thrombin inhibitor, in canine cardiopulmonary bypass and simulated mitral valve repair. J Extra Corpor Technol. 2008 Jun;40(2):116-22. ?
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