Etiprednol dicloacetate

Research use only, not for human use.

Etiprednol dicloacetate (BNP-166) is a corticosteroid with anti-inflammatory activity.

Etiprednol dicloacetate (BNP 166) is an anti-inflammatory agent. Etiprednol dicloacetate inhibits eosinophil accumulation. Etiprednol dicloacetate can be used in the research of inflammatory airway diseases, such as asthma.

Etiprednol dicloacetate (1 nM-1 μM) inhibits LPS-induced TNF-α production by human blood.

Etiprednol dicloacetate (0-100 μg/kg, intranasal inhalation) attenuates peribronchial eosinophilia in the lung of the allergen sensitized and challenged rats.Etiprednol dicloacetate (0.1 μg/kg, intranasal inhalation) inhibits eosinophil accumulation in rats (antigen-induced airway eosinophil infiltration).Etiprednol dicloacetate (0-20 mg/kg, p.o., 28 days) is well tolerated in rats and dogs.Animal Model: Allergen sensitized and challenged Brown Norway rats Dosage:0.1, 1, 10, and 100 μg/kg Administration: Intranasal inhalation Result:Decreased the number of eosinophils at the perivascular area of the lung tissue.Decreased the number of mucus secreting cells and antigen-induced formation of perivascular edema.

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Others

Other Targets

Others

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199331-40-3

485.4

C24H30Cl2O6

>98% (HPLC)

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O(C(C(Cl)Cl)=O)[C@@]1(C(OCC)=O)[C@]2(C)[C@@](CC1)([C@]3([C@]([C@@H](O)C2)([C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H])[H]

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(-20℃)

With Ice Pack

≥ 2 years