Cart
sales@molnova.com
Clitocine
CAS No. 105798-74-1
Clitocine( —— )
Catalog No. M34550 CAS No. 105798-74-1
Clitocine, an adenosine analogue derived from mushrooms, is a potent transcriptional readout agent, an inhibitor of nonsense mutations, and has anticancer activity, inducing the production of p53 protein in cells carrying the p53 nonsense mutation allele.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 302 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameClitocine
-
NoteResearch use only, not for human use.
-
Brief DescriptionClitocine, an adenosine analogue derived from mushrooms, is a potent transcriptional readout agent, an inhibitor of nonsense mutations, and has anticancer activity, inducing the production of p53 protein in cells carrying the p53 nonsense mutation allele.
-
DescriptionClitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity.
-
In VitroClitocine incorporation into mRNA is required for premature stop codon readthrough activity, and the presence of clitocine at the third position of a premature stop codon is sufficient to promote robust readthrough.Clitocine (0-0.8 μM; 24 hours) enhances TRAIL-lethality in in LS411N and SW620 cells. Clitocine (0.2μM; 36 hours) significantly potentiates TRAIL-mediated apoptosis.
-
In VivoCitocine (0.3-3 mg/kg; s.c.; five times per week)-induced p53 inhibits CAOV-33p53-UAA136 tumor growth in a xenograft model.Animal Model:nu/nu mice (CAOV-3p53-UAA136 xenograft tumors)Dosage:0.3, 3 mg/kg (or 20 mg/kg once per week) Administration:S.c.; five times per weekResult:CAOV-33p53-UAA136 tumor growth was inhibited.
-
Synonyms——
-
PathwayApoptosis
-
TargetApoptosis
-
RecptorApoptosis | BCL
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number105798-74-1
-
Formula Weight287.23
-
Molecular FormulaC9H13N5O6
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (348.15 mM; Ultrasonic )
-
SMILESNc1ncnc(N[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1[N+]([O-])=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
-
Epibrassinolide
Epibrassinolide (EBR) is a biologically active compound of the brassinosteroids is a natural brassinosteroid (BR) derivative is a plant regulator with a similar structure to mammalian steroids.
-
Bigelovin
Bigelovin is a selective retinoid X receptor α agonist.?Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation.It is also known as a potent cytotoxic sesquiterpene lactone from Inula sp.
-
HYPOCRELLIN B
HYPOCRELLIN B are photosensitive pigments isolated from Hypocrella bambusae Sacc. Hypocrellin B causes DNA strand breakage induces apoptosis in ovarian cancer cells and inhibits proliferation of Staphylococcus by increasing ROS levels and damaging cell walls.
