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Ticolubant

CAS No. 154413-61-3

Ticolubant( —— )

Catalog No. M34447 CAS No. 154413-61-3

Ticolubant is orally active leukotriene B4 antagonist with high affinity for the human neutrophil LTB4 receptor (Ki = 0.78 nM), blocks LTB4-induced Ca2+ migration with an IC50 of 6.6 ± 1.5 nM, and shows topical anti-inflammatory activity in a mouse model of skin inflammation.

Purity : >98% (HPLC)

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5MG	504	Get Quote
10MG	728	Get Quote
25MG	1086	Get Quote
50MG	1463	Get Quote
100MG	1935	Get Quote
500MG	3861	Get Quote
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Biological Information

Product Name

Ticolubant
Note

Research use only, not for human use.
Brief Description

Ticolubant is orally active leukotriene B4 antagonist with high affinity for the human neutrophil LTB4 receptor (Ki = 0.78 nM), blocks LTB4-induced Ca2+ migration with an IC50 of 6.6 ± 1.5 nM, and shows topical anti-inflammatory activity in a mouse model of skin inflammation.
Description

Ticolubant is orally active leukotriene B4 antagonist with high affinity for the human neutrophil LTB4 receptor (Ki = 0.78 nM), blocks LTB4-induced Ca2+ migration with an IC50 of 6.6 ± 1.5 nM, and shows topical anti-inflammatory activity in a mouse model of skin inflammation.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

GPCR/G Protein
Target

Calcium Channel
Recptor

Calcium Channel | LTR
Research Area

——
Indication

——

Chemical Information

CAS Number

154413-61-3
Formula Weight

460.37
Molecular Formula

C23H19Cl2NO3S
Purity

>98% (HPLC)
Solubility

——
SMILES

C(=C/C(O)=O)\C1=C(OCCC2=CC=CC=C2)C=CC(CSC3=C(Cl)C=CC=C3Cl)=N1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

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