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RL648_81

CAS No. 1919050-87-5

RL648_81( —— )

Catalog No. M34398 CAS No. 1919050-87-5

RL648_81 is a selective activator of KCNQ2/3 channels (EC50 = 190 nM). RL648_81 can be used in studies about neuronal hyperexcitability neurologic disorders.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

RL648_81
Note

Research use only, not for human use.
Brief Description

RL648_81 is a selective activator of KCNQ2/3 channels (EC50 = 190 nM). RL648_81 can be used in studies about neuronal hyperexcitability neurologic disorders.
Description

RL648_81 is a specific KQT-like subfamily 2/3 (KCNQ2/3) activator with an EC50 of 190 nM. RL648_81 robustly shifts the V1/2 of KCNQ2/3 channels towards hyperpolarized potentials.RL648_81 does not shift the V1/2 of either KCNQ4 or KCNQ5.RL648_81 has the potential for neurologic disorders associated with neuronal hyperexcitability research.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

Potassium Channel
Recptor

Potassium Channel
Research Area

——
Indication

——

Chemical Information

CAS Number

1919050-87-5
Formula Weight

371.33
Molecular Formula

C17H17F4N3O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (269.30 mM; Ultrasonic )
SMILES

CCOC(=O)Nc1ccc(NCc2ccc(cc2)C(F)(F)F)c(F)c1N
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Manoj Kumar, et al. Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators. Mol Pharmacol. 2016 Jun;89(6):667-77.?

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