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RL648_81
CAS No. 1919050-87-5
RL648_81( —— )
Catalog No. M34398 CAS No. 1919050-87-5
RL648_81 is a selective activator of KCNQ2/3 channels (EC50 = 190 nM). RL648_81 can be used in studies about neuronal hyperexcitability neurologic disorders.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 40 | In Stock |
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| 5MG | 33 | In Stock |
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| 10MG | 61 | In Stock |
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| 25MG | 136 | In Stock |
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| 50MG | 197 | In Stock |
|
| 100MG | 277 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRL648_81
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NoteResearch use only, not for human use.
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Brief DescriptionRL648_81 is a selective activator of KCNQ2/3 channels (EC50 = 190 nM). RL648_81 can be used in studies about neuronal hyperexcitability neurologic disorders.
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DescriptionRL648_81 is a specific KQT-like subfamily 2/3 (KCNQ2/3) activator with an EC50 of 190 nM. RL648_81 robustly shifts the V1/2 of KCNQ2/3 channels towards hyperpolarized potentials.RL648_81 does not shift the V1/2 of either KCNQ4 or KCNQ5.RL648_81 has the potential for neurologic disorders associated with neuronal hyperexcitability research.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorPotassium Channel
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Research Area——
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Indication——
Chemical Information
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CAS Number1919050-87-5
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Formula Weight371.33
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Molecular FormulaC17H17F4N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (269.30 mM; Ultrasonic )
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SMILESCCOC(=O)Nc1ccc(NCc2ccc(cc2)C(F)(F)F)c(F)c1N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Manoj Kumar, et al. Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators. Mol Pharmacol. 2016 Jun;89(6):667-77.?
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