K6PC-5

Research use only, not for human use.

K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels.

K6PC-5, a ceramide derivative, is a sphingosine kinase 1(SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 has the potential for skin diseases involving abnormal keratinocyte, and neurodegeneration and virus infection research.

Western Blot Analysis Cell Line:Normal human epidermal keratinocytes (NHEKs)Concentration:1 μM, 5 μM, 10 μM Incubation Time:24 h Result:Increased the involucrin and loricrin levels in a dose-dependent manner.Cell Proliferation Assay Cell Line:Human fibroblasts Concentration:1 μM, 5 μM, 10 μM Incubation Time:24 h Result:Promoted fibroblast proliferation and procollagen production in human fibroblasts significantly.

Animal Model:Intrinsically aged hairless mice (56 weeks old) Dosage:1% (vehicle (PEG:EtOH = 7:3)) Administration:Topical application; twice daily for 2 weeks Result:Enhanced fibroblast proliferation, collagen production, and eventually increased dermal thickness.

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GPCR/G Protein

S1P Receptor

S1P Receptor

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756875-51-1

343.5

C19H37NO4

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (291.12 mM; Ultrasonic )

CCCCCCCC(=O)C(CCCCCC)C(=O)NC(CO)CO

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(-20℃)

With Ice Pack

≥ 2 years