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K6PC-5

CAS No. 756875-51-1

K6PC-5( —— )

Catalog No. M34304 CAS No. 756875-51-1

K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    K6PC-5
  • Note
    Research use only, not for human use.
  • Brief Description
    K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels.
  • Description
    K6PC-5, a ceramide derivative, is a sphingosine kinase 1(SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 has the potential for skin diseases involving abnormal keratinocyte, and neurodegeneration and virus infection research.
  • In Vitro
    Western Blot Analysis Cell Line:Normal human epidermal keratinocytes (NHEKs)Concentration:1 μM, 5 μM, 10 μM Incubation Time:24 h Result:Increased the involucrin and loricrin levels in a dose-dependent manner.Cell Proliferation Assay Cell Line:Human fibroblasts Concentration:1 μM, 5 μM, 10 μM Incubation Time:24 h Result:Promoted fibroblast proliferation and procollagen production in human fibroblasts significantly.
  • In Vivo
    Animal Model:Intrinsically aged hairless mice (56 weeks old) Dosage:1% (vehicle (PEG:EtOH = 7:3)) Administration:Topical application; twice daily for 2 weeks Result:Enhanced fibroblast proliferation, collagen production, and eventually increased dermal thickness.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    S1P Receptor
  • Recptor
    S1P Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    756875-51-1
  • Formula Weight
    343.5
  • Molecular Formula
    C19H37NO4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (291.12 mM; Ultrasonic )
  • SMILES
    CCCCCCCC(=O)C(CCCCCC)C(=O)NC(CO)CO
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kwon YB, et al. Novel synthetic ceramide derivatives increase intracellular calcium levels and promote epidermal keratinocyte differentiation. J Lipid Res. 2007 Sep;48(9):1936-43.??
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