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Home - Products - Endocrinology/Hormones - ATPase - FR-167356

FR-167356

CAS No. 174185-16-1

FR-167356( —— )

Catalog No. M34261 CAS No. 174185-16-1

FR-167356 is a specific inhibitor of a3 isoform vacuolar type H -ATPase with IC50s of 170 nM, 370 nM and 220 nM for osteoclast plasma membranes, renal brush border membranes and macrophage microsomes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    FR-167356
  • Note
    Research use only, not for human use.
  • Brief Description
    FR-167356 is a specific inhibitor of a3 isoform vacuolar type H -ATPase with IC50s of 170 nM, 370 nM and 220 nM for osteoclast plasma membranes, renal brush border membranes and macrophage microsomes.
  • Description
    FR-167356 is a potent, orally active and selective vacuolar ATPase inhibitor with IC50 values of 170, 220, 370, and 1200 nM for osteoclast plasma membranes, macrophage microsomes, renal brush border membranes, and liver lysosomal membranes, respectively. FR-167356 inhibits bone resorption and ovariectomy-induced bone loss.
  • In Vitro
    ——
  • In Vivo
    Animal Model:male C57BL/6 mice with B16-F10 xenografts Dosage:200 mg/kg Administration:Oral administration; daily, for 10 days Result:Reduced the expression of MMP9 and reduced bone metastasis.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    ATPase
  • Recptor
    ATPase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    174185-16-1
  • Formula Weight
    378.25
  • Molecular Formula
    C19H17Cl2NO3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(C)(C)(O)C=1C=2C(=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=CC2)OC1C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nishisho T, et, al. The a3 isoform vacuolar type H?-ATPase promotes distant metastasis in the mouse B16 melanoma cells. Mol Cancer Res. 2011 Jul;9(7):845-55.?
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