Cart
sales@molnova.com
Home - Products - Endocrinology/Hormones - ATPase - FR-167356

FR-167356

CAS No. 174185-16-1

FR-167356( —— )

Catalog No. M34261 CAS No. 174185-16-1

FR-167356 is a specific inhibitor of a3 isoform vacuolar type H -ATPase with IC50s of 170 nM, 370 nM and 220 nM for osteoclast plasma membranes, renal brush border membranes and macrophage microsomes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 273 In Stock
10MG 372 In Stock
25MG 563 In Stock
50MG 742 In Stock
100MG 977 In Stock
200MG 1293 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    FR-167356
  • Note
    Research use only, not for human use.
  • Brief Description
    FR-167356 is a specific inhibitor of a3 isoform vacuolar type H -ATPase with IC50s of 170 nM, 370 nM and 220 nM for osteoclast plasma membranes, renal brush border membranes and macrophage microsomes.
  • Description
    FR-167356 is a potent, orally active and selective vacuolar ATPase inhibitor with IC50 values of 170, 220, 370, and 1200 nM for osteoclast plasma membranes, macrophage microsomes, renal brush border membranes, and liver lysosomal membranes, respectively. FR-167356 inhibits bone resorption and ovariectomy-induced bone loss.
  • In Vitro
    ——
  • In Vivo
    Animal Model:male C57BL/6 mice with B16-F10 xenografts Dosage:200 mg/kg Administration:Oral administration; daily, for 10 days Result:Reduced the expression of MMP9 and reduced bone metastasis.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    ATPase
  • Recptor
    ATPase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    174185-16-1
  • Formula Weight
    378.25
  • Molecular Formula
    C19H17Cl2NO3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(C)(C)(O)C=1C=2C(=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=CC2)OC1C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nishisho T, et, al. The a3 isoform vacuolar type H?-ATPase promotes distant metastasis in the mouse B16 melanoma cells. Mol Cancer Res. 2011 Jul;9(7):845-55.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • BTB06584

    BTB06584 is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB).

  • Diazoxide

    Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions.

  • SKF96067

    SKF96067 is a reversible gastric H+/K+-ATPase inhibitor that can induce relaxation of human airway smooth muscle in vitro.

Sign In Join Free