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S3QEL-2

CAS No. 890888-12-7

S3QEL-2( —— )

Catalog No. M34135 CAS No. 890888-12-7

S3QEL-2 is a selective complex III superoxide-producing site inhibitor with neuroprotective effects that inhibits PC-3 cell proliferation in pyruvate-starved medium in a dose-dependent manner.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 42 In Stock
5MG 38 In Stock
10MG 53 In Stock
25MG 100 In Stock
50MG 160 In Stock
100MG 237 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    S3QEL-2
  • Note
    Research use only, not for human use.
  • Brief Description
    S3QEL-2 is a selective complex III superoxide-producing site inhibitor with neuroprotective effects that inhibits PC-3 cell proliferation in pyruvate-starved medium in a dose-dependent manner.
  • Description
    S3QEL-2, a suppressor of superoxide production from mitochondrial complex III, potently and selectively suppresses site IIIQo superoxide production (IC50=1.7 μM). S3QEL-2 does not affect oxidative phosphorylation, and normal electron flux. S3QEL-2 inhibits HIF-1α accumulation.
  • In Vitro
    S3QELs-2 protects against ROS-induced, JNK-mediated cell stress in pancreatic β-cells and S3QEL-2 strongly mitigates the oxidative stress-induced apoptosis that limits the yield of functional β-cells from intact islets.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Mitochondrial Metabolism
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    890888-12-7
  • Formula Weight
    323.44
  • Molecular Formula
    C19H25N5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (154.59 mM; Ultrasonic )
  • SMILES
    N=1C=NC(=C2C=NN(C12)C3=CC=C(C(=C3)C)C)N(CCC)CCC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Orr AL, et al. Suppressors of superoxide production from mitochondrial complex III. Nat Chem Biol. 2015;11(11):834-836.?
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