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Necrostatin-7

CAS No. 351062-08-3

Necrostatin-7( —— )

Catalog No. M34110 CAS No. 351062-08-3

Necrostatin-7 (Necrostatin 7) is an inhibitor of necrotic apoptosis with cardioprotective effects, inhibits RANK-NFATc1 signaling, and attenuates macrophage differentiation into osteoblasts.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 48 In Stock
10MG 83 In Stock
25MG 167 In Stock
50MG 267 In Stock
100MG 429 In Stock
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Biological Information

  • Product Name
    Necrostatin-7
  • Note
    Research use only, not for human use.
  • Brief Description
    Necrostatin-7 (Necrostatin 7) is an inhibitor of necrotic apoptosis with cardioprotective effects, inhibits RANK-NFATc1 signaling, and attenuates macrophage differentiation into osteoblasts.
  • Description
    Necrotatin-7 (Nec-7) is a potent necroptosis inhibitor with an EC50 of 10.6 μM. Necrotatin-7 does not inhibit recombinant RIP1 kinase.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    351062-08-3
  • Formula Weight
    371.41
  • Molecular Formula
    C16H10FN5OS2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1C(SC(=N)N1C2=NC=CS2)=CC3=CNN=C3C=4C=CC(F)=CC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Weihong Zheng, et al. Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4932-5.?
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