PD173952

Research use only, not for human use.

PD173952 is a tyrosine (Src) kinase and Myt1 inhibitor with antitumor activity, inhibits Lyn, Abl and Csk, and induces Bcr-Abl-dependent hematopoietic cell apoptosis.

PD173952 is a tyrosine kinases inhibitor with IC50s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk, respectively. PD173952 is also a potent Myt1 kinase inhibitor with a Ki of 8.1 nM. PD173952 induces apoptosis.

Western Blot Analysis Cell Line:K562 cells Concentration:0, 25, 50, 100, 200, 500 and 1000 nM Incubation Time:12 h Result:Inhibited tyrosine phosphorylation of p210Bcr-Abl and CrkL.Cell Viability Assay Cell Line:K562 cells Concentration:0.5 μM Incubation Time:1-4 days Result:Caused cell death in a time-dependent manner.Western Blot Analysis Cell Line:K562 and MEG-01 cells Concentration:0.5 μM Incubation Time:24 and 48 h Result:85-kDa PARP fragment was detected.

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Angiogenesis

Src

Src | Wee1

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305820-75-1

482.36

C24H21Cl2N5O2

>98% (HPLC)

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O=C1C(=CC=2C=NC(=NC2N1C)NC3=CC=C(C=C3)N4CCOCC4)C5=C(Cl)C=CC=C5Cl

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(-20℃)

With Ice Pack

≥ 2 years