Mepacrine( —— )

Catalog No. M34002 CAS No. 83-89-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Mepacrine
Note

Research use only, not for human use.
Brief Description

Mepacrine (Erion) is an acridine derivative formerly widely used as an antimalarial. It is used in cell biological experiments as an inhibitor of phospholipase A2.
Description

Quinacrine (Acriquine) is an antimalarial and anti-cancer agent. Quinacrine also inhibits human aldehyde oxidase (IC50: 3.3 μM). Quinacrine has affinity for nucleic acids, and stains DNA and RNA in fixed cells (Ex/Em: 436/525 nm).
In Vitro

Cell Viability Assay Cell Line:SGC-7901 cell Concentration:0, 5, 10, 15, 20 μM Incubation Time:24 h Result:Inhibited cell growth with an IC50 value of 16.18 μM.
In Vivo

Animal Model:Acute kidney injury rat model Dosage:3-30 mg/kg Administration:i.p.Result:Attenuated glycerol induced structural and functional changes in kidney.
Synonyms

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Pathway

Others
Target

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Recptor

Others
Research Area

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Indication

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1. Vogtherr M, et al. Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein. J Med Chem. 2003 Aug 14;46(17):3563-4. ?

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