KS370G

Research use only, not for human use.

KS370G (Caffeic Acid Phenethyl Amide) inhibits UUO-induced renal fibrosis marker expression.

KS370G is an orally active hypoglycemic and cardiovascular protective agent. KS370G improves left ventricular hypertrophy and function in pressure-overload mice heart. KS370G reduces renal obstructive nephropathy.

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Animal Model:Pressure-overload ICR mice modelDosage:1 mg/kgAdministration:Oral gavage, once daily for 8 weeksResult:Inhibited cardiac hypertrophy and improved cardiac function induced by pressure overload. Decreased the plasma levels of atrial natriuretic peptide and lactate dehydrogenase. Significantly reduced pressure overload-induced increase of α-SMA and phosphorylation of ERK, AKT and GSK3β. Reduced cardiac collagen accumulation.Animal Model:Male ICR mice, unilateral ureteral obstruction (UUO) modelDosage:10 mg/kg Administration:Oral, once daily for 13 days Result:Significantly attenuated collagen deposition in the obstructed kidney and inhibited UUO-induced renal fibrosis markers expression, including fibronectin, type I collagen, vimentin, and α-smooth muscle actin (α-SMA). Significantly lowered the expression of renal inflammatory chemokines/adhesion molecules and monocyte cells marker (MCP-1, VCAM-1, ICAM-1 and CD11b). Reduced renal malondialdehyde levels and reversed the expression of renal antioxidant enzymes (SOD and catalase) after UUO. Significantly inhibited UUOinduced elevated plasma AngII and TGF-β1 levels, TGF-β1 protein expression and Smad3 phosphorylation.

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Others

Other Targets

Others

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105955-01-9

283.32

C17H17NO3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (352.96 mM; Ultrasonic )

C(=CC(NCCC1=CC=CC=C1)=O)C2=CC(O)=C(O)C=C2

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(-20℃)

With Ice Pack

≥ 2 years