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ISX-1
CAS No. 909207-35-8
ISX-1( —— )
Catalog No. M33990 CAS No. 909207-35-8
ISX-1 inhibits adipogenesis and promotes osteoblastogenesis. ISX-1 can be used in studies about osteoporosis and osteopenia.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 223 | In Stock |
|
| 5MG | 207 | In Stock |
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| 10MG | 293 | In Stock |
|
| 25MG | 452 | In Stock |
|
| 50MG | 631 | In Stock |
|
| 100MG | 870 | In Stock |
|
| 200MG | 1172 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameISX-1
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NoteResearch use only, not for human use.
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Brief DescriptionISX-1 inhibits adipogenesis and promotes osteoblastogenesis. ISX-1 can be used in studies about osteoporosis and osteopenia.
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DescriptionISX-1 is an isoxazole. ISX-1 has anti-adipogenic and pro-osteogenic activities. ISX-1 can be used for the research of osteopenia and osteoporosis.
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In VitroRT-PCRCell Line:Human bone marrow mesenchymal stem cells (hBMSCs)Concentration:0, 1.3, 6.5 and 33 μM Incubation Time:3 days Result:Inhibited the mRNA induction of PPARγ and FABP4 genes under the adipogenic differentiation of hBMSCs and showed no effect on C/EBPα expression.Western Blot Analysis Cell Line:HEK 293 cells Concentration:6.5 and 33 μM Incubation Time:6.5 and 33 μM Result:Increased both the amount of activated and total β-catenin.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number909207-35-8
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Formula Weight302.35
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Molecular FormulaC14H14N4O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (165.37 mM; Ultrasonic )
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SMILESC(NCCCN1C=CN=C1)(=O)C=2C=C(ON2)C3=CC=CS3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nawa, Katsuhiko et al. Discovering small molecules that inhibit adipogenesis and promote osteoblastogenesis: unique screening and Oncostatin M-like activity. Differentiation. 2013 Jul-Sep;86(1-2):65-74. ?
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