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ISX-1

CAS No. 909207-35-8

ISX-1( —— )

Catalog No. M33990 CAS No. 909207-35-8

ISX-1 inhibits adipogenesis and promotes osteoblastogenesis. ISX-1 can be used in studies about osteoporosis and osteopenia.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 223 In Stock
5MG 207 In Stock
10MG 293 In Stock
25MG 452 In Stock
50MG 631 In Stock
100MG 870 In Stock
200MG 1172 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    ISX-1
  • Note
    Research use only, not for human use.
  • Brief Description
    ISX-1 inhibits adipogenesis and promotes osteoblastogenesis. ISX-1 can be used in studies about osteoporosis and osteopenia.
  • Description
    ISX-1 is an isoxazole. ISX-1 has anti-adipogenic and pro-osteogenic activities. ISX-1 can be used for the research of osteopenia and osteoporosis.
  • In Vitro
    RT-PCRCell Line:Human bone marrow mesenchymal stem cells (hBMSCs)Concentration:0, 1.3, 6.5 and 33 μM Incubation Time:3 days Result:Inhibited the mRNA induction of PPARγ and FABP4 genes under the adipogenic differentiation of hBMSCs and showed no effect on C/EBPα expression.Western Blot Analysis Cell Line:HEK 293 cells Concentration:6.5 and 33 μM Incubation Time:6.5 and 33 μM Result:Increased both the amount of activated and total β-catenin.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    909207-35-8
  • Formula Weight
    302.35
  • Molecular Formula
    C14H14N4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (165.37 mM; Ultrasonic )
  • SMILES
    C(NCCCN1C=CN=C1)(=O)C=2C=C(ON2)C3=CC=CS3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nawa, Katsuhiko et al. Discovering small molecules that inhibit adipogenesis and promote osteoblastogenesis: unique screening and Oncostatin M-like activity. Differentiation. 2013 Jul-Sep;86(1-2):65-74. ?
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