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TC LPA5 4
CAS No. 1393814-38-4
TC LPA5 4( —— )
Catalog No. M33938 CAS No. 1393814-38-4
TC LPA5 4 is a LPA5 receptor antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 109 | In Stock |
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| 5MG | 100 | In Stock |
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| 10MG | 160 | In Stock |
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| 25MG | 341 | In Stock |
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| 50MG | 500 | In Stock |
|
| 100MG | 737 | In Stock |
|
| 200MG | 1014 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTC LPA5 4
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NoteResearch use only, not for human use.
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Brief DescriptionTC LPA5 4 is a LPA5 receptor antagonist.
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DescriptionTC LPA5 4 is a LPA5 (GPR92)-specific non-lipid antagonist. TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelet (LPA5-RH7777 cell line) with an IC50 of 800 nM. TC LPA5 4 displays selectivity for LPA5 over 80 other screened agent targets. TC LPA5 4 inhibits cell proliferation and migration of thyroid cancer cells.
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In Vitro——
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In VivoAnimal Model:BALB/C nu/nu mice, aged 4 5 weeks (CGTH-W3 xenografts) Dosage:10 mg/kg Administration:Intraperitoneal injection; 5 days/week for 2 weeks Result:Significantly inhibits CGTH-W3 xenograft growth with inhibitory rates of 46.7%.
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Synonyms——
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PathwayGPCR/G Protein
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TargetLPA Receptor
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RecptorLPA Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1393814-38-4
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Formula Weight410.89
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Molecular FormulaC23H23ClN2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (152.11 mM; Ultrasonic )
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SMILESC(O)(=O)C=1C=C(N(N1)C2=CC(OC)=CC=C2)C3=CC(Cl)=C(C=C3)C4CCCCC4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kozian DH, et al. Selective non-lipid modulator of LPA5 activity in human platelets. Bioorg Med Chem Lett. 2012;22(16):5239-5243.?
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