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(S)-(+)-Dimethindene maleate

CAS No. 136152-65-3

(S)-(+)-Dimethindene maleate( —— )

Catalog No. M33918 CAS No. 136152-65-3

(S)-(+)-Dimethindene maleate is an orally available, selective muscarinic M2 receptor and histamine H1 receptor antagonist that also inhibits muscarinic M1, M3, and M4 receptors.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    (S)-(+)-Dimethindene maleate
  • Note
    Research use only, not for human use.
  • Brief Description
    (S)-(+)-Dimethindene maleate is an orally available, selective muscarinic M2 receptor and histamine H1 receptor antagonist that also inhibits muscarinic M1, M3, and M4 receptors.
  • Description
    (S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M1 (pA2 = 6.83/6.36; pKi = 7.08), the M3 (pA2 = 6.92/6.96; pKi = 6.70) and the M4 receptors (pKi = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.48).
  • In Vitro
    Cell Viability Assay Cell Line:Mouse EPS cells Concentration:2 μM Incubation Time:1 hour Result:Significantly impaired the developmental potency of mEPS cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    AChR
  • Recptor
    AChR | Histamine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    136152-65-3
  • Formula Weight
    408.49
  • Molecular Formula
    C24H28N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (244.80 mM; Ultrasonic )
  • SMILES
    OC(=O)\C=C/C(O)=O.C[C@@H](C1=C(CCN(C)C)Cc2ccccc12)c1ccccn1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Pfaff O, et al. The (S)-(+)-enantiomer of dimethindene: a novel M2-selective muscarinic receptor antagonist. Eur J Pharmacol. 1995;286(3):229-240.?
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