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(S)-(+)-Dimethindene maleate
CAS No. 136152-65-3
(S)-(+)-Dimethindene maleate( —— )
Catalog No. M33918 CAS No. 136152-65-3
(S)-(+)-Dimethindene maleate is an orally available, selective muscarinic M2 receptor and histamine H1 receptor antagonist that also inhibits muscarinic M1, M3, and M4 receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product Name(S)-(+)-Dimethindene maleate
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NoteResearch use only, not for human use.
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Brief Description(S)-(+)-Dimethindene maleate is an orally available, selective muscarinic M2 receptor and histamine H1 receptor antagonist that also inhibits muscarinic M1, M3, and M4 receptors.
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Description(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M1 (pA2 = 6.83/6.36; pKi = 7.08), the M3 (pA2 = 6.92/6.96; pKi = 6.70) and the M4 receptors (pKi = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.48).
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In VitroCell Viability Assay Cell Line:Mouse EPS cells Concentration:2 μM Incubation Time:1 hour Result:Significantly impaired the developmental potency of mEPS cells.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetAChR
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RecptorAChR | Histamine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number136152-65-3
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Formula Weight408.49
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Molecular FormulaC24H28N2O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (244.80 mM; Ultrasonic )
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SMILESOC(=O)\C=C/C(O)=O.C[C@@H](C1=C(CCN(C)C)Cc2ccccc12)c1ccccn1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Pfaff O, et al. The (S)-(+)-enantiomer of dimethindene: a novel M2-selective muscarinic receptor antagonist. Eur J Pharmacol. 1995;286(3):229-240.?
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