Rimcazole dihydrochloride( —— )

Catalog No. M33914 CAS No. 75859-03-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Rimcazole dihydrochloride
Note

Research use only, not for human use.
Brief Description

Rimcazole dihydrochloride is the hydrochloride salt of Rimcazole, a σ receptor antagonist. Rimcazole dihydrochloride also binds to dopamine transporter proteins and inhibits dopamine uptake.
Description

Rimcazole (BW 234U) dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the dopamine transporter and inhibit dopamine uptake. Rimcazole dihydrochloride can reduce locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer.
In Vitro

Western Blot AnalysisCell Line:HCT-116p53+/+ cells Concentration:50 μM Incubation Time:1, 2, 3, 5, 6, 24 hours Result:Accumulation of HIF-1α protein, maximal at 6?h.No change in p53 protein levels.HIF-1α protein levels returned to normal steady-state levels within 24?h.
In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

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Indication

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CAS Number

75859-03-9
Formula Weight

357.92
Molecular Formula

C21H28ClN3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 12.5 mg/mL (31.70 mM; Ultrasonic (<60°C); )H2O : < 0.1 mg/mL (insoluble)
SMILES

Cl.Cl.C[C@H]1CN(CCCn2c3ccccc3c3ccccc23)C[C@@H](C)N1
Chemical Name

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1. Gilmore DL, et, al. Review of the pharmacological and clinical profile of rimcazole. CNS Drug Rev. Spring 2004;10(1):1-22.?

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