PAOPA

Research use only, not for human use.

dopamine D2 receptor modulator

PAOPA, an analog of L-proline-l-leucine-glycine amide (PLG) peptide, is an allosteric modulator of Dopamine D2 Receptor. PAOPA can effectively reduce behavioral abnormalities in rodent models of schizophrenia. PAOPA increases the high affinity dopamine D2 receptor and promotes its binding to agonists.

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PAOPA (1 mg/kg; i.p.; once daily for 45 d) in chronic administration induces increased expression of D2 receptor regulation and downstream molecules (including GRK2, arrestin-3, and extracellular receptor kinase ERK 1/2) in mice.

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Others

Other Targets

Others

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114200-31-6

254.29

C11H18N4O3

>98% (HPLC)

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N(C(=O)[C@@H]1CCCN1)[C@H]2C(=O)N(CC(N)=O)CC2

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(-20℃)

With Ice Pack

≥ 2 years