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NU 9056
CAS No. 1450644-28-6
NU 9056( —— )
Catalog No. M33896 CAS No. 1450644-28-6
NU 9056 is an effective and selective inhibitor of KAT5 histone acetyltransferase with an IC50 of 2 μM. NU 9056 blocks DNA damage response and inhibits protein acetylation in prostate cancer cell lines.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 167 | In Stock |
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| 2MG | 93 | In Stock |
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| 5MG | 150 | In Stock |
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| 10MG | 235 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNU 9056
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NoteResearch use only, not for human use.
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Brief DescriptionNU 9056 is an effective and selective inhibitor of KAT5 histone acetyltransferase with an IC50 of 2 μM. NU 9056 blocks DNA damage response and inhibits protein acetylation in prostate cancer cell lines.
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DescriptionNU9056 is a potent and selective Tip60 (KAT5) histone acetyltransferase inhibitor with an of 2 μM. NU9056 shows >16-fold selectivity for Tip60 over PCAF, p300 and GCN5. NU9056 induces apoptosis of prostate cancer cells.
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In VitroApoptosis Analysis Cell Line:LNCaP cellsConcentration:17 μM, 24 μM, 36 μM Incubation Time:24 hours, 48 hours, 72 hours, 96 hours Result:Induced apoptosis via activation of caspase 3 and caspase 9 in a concentration- and time-dependent manner. Western Blot Analysis Cell Line:LNCaP cells Concentration:2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM Incubation Time:2 hours Result:Resulted in decreased levels of acetylated histone H4K16, H3K14 and H4K8, targets for Tip60-mediated acetylation.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorHistone Acetyltransferase
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Research Area——
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Indication——
Chemical Information
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CAS Number1450644-28-6
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Formula Weight232.37
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Molecular FormulaC6H4N2S4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (537.94 mM; Ultrasonic )
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SMILESS(Sc1ccns1)c1ccns1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kelly Coffey, et al. Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS One. 2012;7(10):e45539.?
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