N-Arachidonylglycine

Research use only, not for human use.

N-Arachidonylglycine (NA-Gly) is a heat-dependent circulating metabolite with anti-inflammatory, anticancer, antidiabetic and antioxidant activities.

N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration.

N-Arachidonylglycine (0.1 nM-100 μM; 5 min) drives MAPK activation in GPR18-transfected HEK293 cells.N-Arachidonylglycine shows no activity at GLYT1 or GAT1 at concentrations up to 100 μm.Western Blot Analysis Cell Line:HEK293-GPR18 cells Concentration:0.1 nM-100 μM Incubation Time:5 minResult:Drove MAPK activation.

N-Arachidonylglycine (10 mg/kg; oral) increases blood concentrations of anandamide 9-fold.N-Arachidonylglycine (1.2 mg/kg; oral; once) results in a significant 70% reduction of peritoneal cells.Animal Model:Rats Dosage:10 mg/kg Administration:Oral Result:Inhibition of FAAH, causing a reduction in the hydrolytic cleavage of anandamid.Animal Model:Mouse (peritonitis model)Dosage:1.2 mg/kg Administration:Oral; once Result:Resulted in a significant 70% reduction of peritoneal cells.

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Others

Antioxidant

Antioxidant

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179113-91-8

361.52

C22H35NO3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (276.61 mM; Ultrasonic (<60°C); )Ethanol : 50 mg/mL (138.30 mM; Ultrasonic)

CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCC(O)=O

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(-20℃)

With Ice Pack

≥ 2 years