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FFN 511

CAS No. 1004548-96-2

FFN 511( —— )

Catalog No. M33849 CAS No. 1004548-96-2

Fluorescent false neurotransmitter (FFN)

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    FFN 511
  • Note
    Research use only, not for human use.
  • Brief Description
    Fluorescent false neurotransmitter (FFN)
  • Description
    FFN511 is a potent fluorescent false neurotransmitters (FFNs) that targets neuronal vesicular monoamine transporter 2 (VMA T2). FFN511 inhibits serotonin binding to VMA T2-containing membranes with an IC50 of 1 μM. FFN511 directly images the dynamics of release during exocytosis, can be used to label dopamine terminals in live cortical-striatalacute slices.
  • In Vitro
    FFN511 (350 nM; 30 min) accumulats in a pattern consistent with LDCVs in cultured mouse chromaffin cells, and the accumulation is abolished by the lipophilic base chloroquine.Cell Viability Assay Cell Line:mouse chromaffin cells Concentration:350 nM Incubation Time:30 min Result:Accumulated in cultured mouse chromaffin cells (the same as LDCVs), and the accumulation could be abolished by the lipophilic base chloroquine, which collapses the vesicle pH gradient.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1004548-96-2
  • Formula Weight
    284.35
  • Molecular Formula
    C17H20N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1OC2=C(C=C3C4=C2CCCN4CCC3)C(=C1)CCN
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gubernator NG, et al. Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals. Science. 2009 Jun 12;324(5933):1441-4.?
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