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DiMNF

CAS No. 14756-24-2

DiMNF( —— )

Catalog No. M33844 CAS No. 14756-24-2

DiMNF is a selective aryl hydrocarbon receptor (AHR) modulator. It also suppresses the expression of CD55 and CD46 induced by IL-1β in an inflammatory tumor cell microenvironment.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DiMNF
  • Note
    Research use only, not for human use.
  • Brief Description
    DiMNF is a selective aryl hydrocarbon receptor (AHR) modulator. It also suppresses the expression of CD55 and CD46 induced by IL-1β in an inflammatory tumor cell microenvironment.
  • Description
    DiMNF (3',4'-Dimethoxy-αNF) is a selective aryl hydrocarbon receptor (AHR) modulator. DiMNF is a competitive AHR ligand (IC50 = 21 nM) with apparent antagonistic activity. DiMNF can be used as an anti-inflammatory agent.
  • In Vitro
    DiMNF (3',4'-Dimethoxy-αNF) (10 μM; 4 h) minimally influences AHR gene battery.DiMNF (10 μM; 1 h) effectively suppresses cytokine-mediated inflammatory gene expression.DiMNF adopts a unique orientation within the ligand binding pocket of AHR.RT-PCR Cell Line:Huh7 cell Concentration:10 μM Incubation Time:4 h or 1 h Result:Decreased CYP1A1 mRNA expression (4 h). Exhibited repressive activity toward cytokine-mediated SAA1 induction (1 h). Significantly reduced IL1β-mediated mRNA induction of C4, C1S, C1R, and C3.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    14756-24-2
  • Formula Weight
    332.35
  • Molecular Formula
    C21H16O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 12.5 mg/mL (37.61 mM; Ultrasonic (<70°C)
  • SMILES
    COc1ccc(cc1OC)-c1cc(=O)c2ccc3ccccc3c2o1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Murray IA, et al. Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-α-naphthoflavone. Mol Pharmacol. 2011 Mar;79(3):508-19.?
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