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CFM 4
CAS No. 331458-02-7
CFM 4( —— )
Catalog No. M33838 CAS No. 331458-02-7
CFM 4 is a potent small molecule CARP-1/APC-2 antagonist that prevents CARP-1 from binding to APC-2, contributes to G2M cell cycle arrest, and induces apoptosis, with an IC50 in the range of 10-15 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 33 | In Stock |
|
| 5MG | 53 | In Stock |
|
| 10MG | 86 | In Stock |
|
| 25MG | 174 | In Stock |
|
| 50MG | 256 | In Stock |
|
| 100MG | 375 | In Stock |
|
| 200MG | 528 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCFM 4
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NoteResearch use only, not for human use.
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Brief DescriptionCFM 4 is a potent small molecule CARP-1/APC-2 antagonist that prevents CARP-1 from binding to APC-2, contributes to G2M cell cycle arrest, and induces apoptosis, with an IC50 in the range of 10-15 μM.
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DescriptionCFM-4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM-4 prevents CARP-1 binding with APC-2, causes G2M cell cycle arrest, and induces apoptosis with an IC50 range of 10-15 μM. CFM-4 also suppresses growth of drug-resistant human breast cancer cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorAPC | Apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number331458-02-7
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Formula Weight405.9
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Molecular FormulaC22H16ClN3OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (61.59 mM; Ultrasonic (<60°C)
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SMILESO=C1C2(C=3C(N1CC4=C(Cl)C=CC=C4)=CC=CC3)SC(=NN2)C5=CC=CC=C5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Puliyappadamba VT, et al. Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. J Biol Chem. 2011 Nov 4;286(44):38000-38017.?
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