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Levocetirizine Dihydrochloride
CAS No. 130018-87-0
Levocetirizine Dihydrochloride( —— )
Catalog No. M33806 CAS No. 130018-87-0
Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 41 | In Stock |
|
| 25MG | 72 | In Stock |
|
| 50MG | 122 | In Stock |
|
| 100MG | 178 | In Stock |
|
| 200MG | 267 | In Stock |
|
| 500MG | 462 | In Stock |
|
| 1G | 656 | In Stock |
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Biological Information
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Product NameLevocetirizine Dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionLevocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor.
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DescriptionLevocetirizine dihydrochloride ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Levocetirizine dihydrochloride is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine dihydrochloride has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria.
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In Vitro——
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In VivoLevocetirizine (0.4 mg/kg; oral administration; male Sprague-Dawley rats) treatment shows that the Cmax, AUC0-t , AUC0-∞ and t1/2 are 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively in Sprague-Dawley rats.Animal Model:30 male Sprague-Dawley rats (8 weeks old; 200-250 g) Dosage:0.4 mg/kg Administration:Oral administration (Pharmacokinetic Analysis)Result:The Cmax, AUC0-t , AUC0-∞ and t1/2 were 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively.
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Synonyms——
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PathwayGPCR/G Protein
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TargetHistamine Receptor
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RecptorHistamine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number130018-87-0
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Formula Weight461.81
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Molecular FormulaC21H27Cl3N2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (216.54 mM; Ultrasonic )H2O : 100 mg/mL (216.54 mM; Ultrasonic)
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SMILESO=C(O)COCCN1CCN([C@@H](C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1.Cl.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lohar P, et al. Simultaneous bioanalysis and pharmacokinetic interaction study of acebrophylline, levocetirizine and pranlukast in Sprague-Dawley rats. Biomed Chromatogr. 2019 Dec;33(12):e4672.?
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