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Pyoluteorin
CAS No. 25683-07-2
Pyoluteorin( —— )
Catalog No. M33757 CAS No. 25683-07-2
Pyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses related plant diseases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 423 | In Stock |
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| 5MG | 472 | In Stock |
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| 10MG | 658 | In Stock |
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| 25MG | 1026 | In Stock |
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| 50MG | 1349 | In Stock |
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| 100MG | 1823 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 3655 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePyoluteorin
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NoteResearch use only, not for human use.
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Brief DescriptionPyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses related plant diseases.
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DescriptionPyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses plant diseases caused by this fungus. Pyoluteorin induces human triple-negative breast cancer MDA-MB-231 cells apoptosis in vitro. Pyoluteorin can be used for the research of human triple-negative breast cancer.
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In VitroPyoluteorin is an antifungal compound composed of a bichlorinated pyrrole linked to a resorcinol moiety, were identified within a 24-kb genomic region of Pseudomonas fluorescens Pf-5.Pyoluteorin has significant cytotoxicity towards MCF-7 (IC50=1.84 μM). Pyoluteorin also displays significantly selective cytotoxicity against BT474, HCC1954, MAD-MB-468, MDA-MB-231, and MCF-10A cells with IC50s of 9.75±0.16, 0.94±0.01, 3.89±0.08, 0.97±0.01, and 57.01±0.76 μM, respectively.Pyoluteorin (0.1-10 μM; for 24 hours) induces change of apoptosis-related protein expressions. Pyoluteorin-induced cell apoptosis in MDA-MB-231 is related to Bcl-2 family proteins and caspase cascade.Pyoluteorin (0.1-10 μM; for 24 h) induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231.Cell Proliferation Assay Cell Line:Human triple-negative breast cancer cell MDA-MB-231 Concentration:0, 0.032, 0.16, 0.8, 4, 20, 100 μM Incubation Time:24, 48, 72 hours Result:Inhibited cells proliferation in a dose- and time-dependent manner. Western Blot Analysis Cell Line:MDA-MB-231 cells Concentration:0.1, 0.3, 1, 3, 10 μM Incubation Time:24 hours Result:The levels of the anti-apoptotic proteins Bcl-2, Bcl-XL and PARP were obviously decreased while the pro-apoptotic proteins BAX and caspase 3 were increased in a dose-dependent manner.
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In Vivo——
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Synonyms——
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PathwayMicrobiology/Virology
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TargetAntibiotic
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RecptorAntibiotic
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Research Area——
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Indication——
Chemical Information
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CAS Number25683-07-2
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Formula Weight272.08
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Molecular FormulaC11H7Cl2NO3
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Purity>98% (HPLC)
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Solubility——
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SMILESOc1cccc(O)c1C(=O)c1cc(Cl)c(Cl)[nH]1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. B Nowak-Thompson, et al. Characterization of the pyoluteorin biosynthetic gene cluster of Pseudomonas fluorescens Pf-5. J Bacteriol. 1999 Apr;181(7):2166-74.?
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