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CP 465022
CAS No. 199655-36-2
CP 465022( —— )
Catalog No. M33746 CAS No. 199655-36-2
CP 465022 hydrochloride is a potent, and selective noncompetitive antagonist of AMPA receptor with anticonvulsant activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 46 | In Stock |
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| 10MG | 72 | In Stock |
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| 25MG | 153 | In Stock |
|
| 50MG | 269 | In Stock |
|
| 100MG | 376 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCP 465022
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NoteResearch use only, not for human use.
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Brief DescriptionCP 465022 hydrochloride is a potent, and selective noncompetitive antagonist of AMPA receptor with anticonvulsant activity.
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DescriptionCP-465022 is a potent, and selective noncompetitive AMPA receptor antagonist with anticonvulsant activity. CP-465022 is against Kainate-induced response with an IC50 of 25 nM in rat cortical neurons. CP-465022 provides a new tool to investigate the role of AMPA receptors in physiological and pathophysiological processes.
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In VitroCP-465022 1 μM for 10 min has little effect on peak NMDA-induced currents but reduces current measured at 8 s during NMDA application by 26%.CP-465,022 at 10 μM inhibits peak NMDA-induced currents in cortical neurons by 36% and currents measured at 8 s by 70% d in primary cultures of cortical and cerebellar granule neurons.CP-465022 1 μM for 10 min inhibits peak NMDA currents in cultured rat cerebellar granule neurons with mean inhibition of 19% and NMDA currents measured at 8 s by 45%, similar to what is observed in the cortical neurons.CP-465022 (100 nM -10 μM) has inhibitory effects on Kainate-induced whole-cell currents in voltage-clamped rat hippocampal, 100 nM CP465,022 inhibits kainate currents developed over the course of 200s, 500 nM and 1 μM CP-465,022 nearly complete inhibits this time frame (99.3%).
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetiGluR
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RecptoriGluR
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Research Area——
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Indication——
Chemical Information
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CAS Number199655-36-2
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Formula Weight462.95
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Molecular FormulaC26H24ClFN4O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (108.00 mM; Ultrasonic )
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SMILESCCN(CC)Cc1cccc(C=Cc2nc3ccc(F)cc3c(=O)n2-c2ccccc2Cl)n1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. J T Lazzaro, et al. Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist. Neuropharmacology. 2002 Feb;42(2):143-53.?
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