Stepronin

Research use only, not for human use.

Stepronin (TTPG) shows expectorant activities and inhibits airway secretion.

Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands.

Stepronin (0.1-100 μM; 20 min) induces significant reductions in ISOP(Isoproterenol)-evoked SCC (short circuit current) value in a dose-dependent manner in canine tracheal epithelium.Stepronin (10-100 μM; 20 min) significantly inhibits the basal secretion and ISOP-evoked PD (potential difference) value in a dose-dependent manner in canine tracheal epithelium.Stepronin (100 μM; 20 min) significantly inhibits ISOP-induced [3H]-glycoconjugate secretion in submucosal glands.Cell Viability Assay Cell Line: Canine tracheal epithelium (from adult and 10 to 25 kg-weight mongrel dogs of both sexes)Concentration:0.1-100 μM; 10-100 μMIncubation Time:20 min (pre-treat) Result:Significantly inhibited ISOP-induced SCC and PD values, as well as basal secretion. Cell Viability Assay Cell Line:Submucosal glands (from adult and 10 to 25 kg-weight mongrel dogs of both sexes) Concentration:100 μM Incubation Time:20 min (pre-treat) Result:Significantly inhibited ISOP- induced [3H]-glycoconjugate secretion.

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Others

Other Targets

Others

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72324-18-6

273.33

C10H11NO4S2

>98% (HPLC)

In Vitro:?DMSO : ≥ 250 mg/mL (914.65 mM)

CC(SC(=O)c1cccs1)C(=O)NCC(O)=O

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(-20℃)

With Ice Pack

≥ 2 years