Alclometasone dipropionate

Research use only, not for human use.

Alclometasone dipropionate （Sch 22219） is a synthetic glucocorticoid, a steroidal compound with antiproliferative, anti-inflammatory, anti-allergic, antipruritic, and vasoconstrictive properties, which is used in the study of skin inflammation.

Alclometasone dipropionate (Sch 22219) is a steroid compound. Alclometasone dipropionate can be used for the research of dermatitis and skin itch.

Alclometasone dipropionate (0.01-100 ng/mL; 24 h) suppresses cytokine production of CD3/CD2 stimulation with IC50s of 5.54, 1.76, 2.09, 0.89, 3.26 and 0.76 ng/mL for IL-2, IL-3, IL-4, IL-5, IFN-γ and GM-CSF, respectively in human PBMC.

Alclometasone dipropionate (0.1% (20 μL); both sides of the ears; once) shows effects on tuberculin- and egg albumin-induced allergic reaction.Animal Model:Lewis rats with tuberculin-induced delayed allergic reactionDosage:0.1% (20 μL)Administration:Both sides of the ears; 0.1% (20 μL) 3 h before and 2 h after tuberculin challenge Result:Partially inhibited the increase in amount of dye leaked.Animal Model:Brown-Norway rats with egg albumin-induced passive cutaneous anaphylaxis reaction Dosage:0.1% (20 μL) Administration:Both sides of the ears; 0.1% (20 μL) 6 h before egg albumin challenge Result:Significantly suppressed the increase in amount of dye leaked in this passive cutaneous anaphylaxis reaction.

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Others

Other Targets

Others

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66734-13-2

521.04

C28H37ClO7

>98% (HPLC)

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C(COC(CC)=O)(=O)[C@]1(OC(CC)=O)[C@]2(C)[C@@](C[C@H]1C)([C@]3([C@]([C@@H](O)C2)([C@]4(C)C(C[C@H]3Cl)=CC(=O)C=C4)[H])[H])[H]

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(-20℃)

With Ice Pack

≥ 2 years