Dasatinib carbaldehyde( —— )

Catalog No. M33555 CAS No. 2112837-79-1

Dasatinib carbaldehyde (PROTAC ABL binding moiety 4) is based on Dasatinib which is an ABL inhibitor, binds to the IAP ligand via a linker, and forms SNIPER .

Purity : >98% (HPLC)

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Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Dasatinib carbaldehyde
Note

Research use only, not for human use.
Brief Description

Dasatinib carbaldehyde (PROTAC ABL binding moiety 4) is based on Dasatinib which is an ABL inhibitor, binds to the IAP ligand via a linker, and forms SNIPER .
Description

Dasatinib carbaldehyde (BMS-354825 carbaldehyde), the Dasatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Ligands for Target Protein for PROTAC
Research Area

——
Indication

——

Chemical Information

CAS Number

2112837-79-1
Formula Weight

471.96
Molecular Formula

C21H22ClN7O2S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 33.33 mg/mL (70.62 mM; Ultrasonic )
SMILES

N(C1=CC(N2CCN(C=O)CC2)=NC(C)=N1)C=3SC(C(NC4=C(C)C=CC=C4Cl)=O)=CN3
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.?

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