Gly-Gly-Gly-PEG4-DBCO( —— )

Catalog No. M33551 CAS No. 2353409-80-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Gly-Gly-Gly-PEG4-DBCO
Note

Research use only, not for human use.
Brief Description

Gly-Gly-Gly-PEG4-DBCO is a degradable ADC linker containing 4 units of PEG, which can be used to synthesize antibody-conjugated active molecules (ADCs).
Description

Gly-Gly-Gly-PEG4-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Gly-Gly-Gly-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
In Vivo

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Synonyms

——
Pathway

Antibody Drug Conjugates (ADC)
Target

ADCs Linker/Click Chemistry
Recptor

ADC Linker
Research Area

——
Indication

——

CAS Number

2353409-80-8
Formula Weight

694.77
Molecular Formula

C35H46N6O9
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (143.93 mM; Ultrasonic )Methanol : 50 mg/mL (71.97 mM; Ultrasonic)
SMILES

O=C(NCC(=O)NCC(=O)NCCOCCOCCOCCOCCNC(=O)CCC(=O)N1C=2C=CC=CC2C#CC=3C=CC=CC3C1)CN
Chemical Name

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1. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.?

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